James mixson 1 1 department of pathology, university of maryland school of medicine, 10 s. To overcome these limitations ligand targeted liposomes were developed. Ligandconjugated liposomes are designed to target receptors which are overexpressed on tumor cells to decrease drugs side effects by. Antibody or ligandmediated targeting of liposomal anticancer drugs to antigens expressed selectively or overexpressed on tumor cells is increasingly being recognized as an effective strategy for increasing the therapeutic indices of anticancer drugs. They enhance the therapeutic index of anticancer drugs by increasing the drug concentration in tumor cells through tumor targeting. Ligandtargeted liposomes for cancer treatment bentham. The potential to alter pharmaceutical properties is of particular importance in anticancer drugs where targeted delivery of the agent will improve its effect on malignant cells whilst minimizing. The discovery of phospholipids spontaneously forming spherical, selfclosed bubbles known as liposomes, upon dispersion in water, ushered a new era in drug delivery technology.
Development of ligandtargeted liposomes for cancer therapy. In this context, encapsulation of anticancer drugs within the liposomal system. Qianyu zhang, jie tang, rui ran, yayuan liu, zhirong zhang, huile gao, qin he. Moreover, the penetration of anticancer drugs into tumor tissues is. Ligand, target, some types of cancer that overexpress the target cell. Liposomal nanoparticles loaded with doxorubicin, and targeted against the. Liposomes as carriers of anticancer drugs intechopen. The design of peptideamphiphiles as functional ligands for liposomal anticancer drug and gene delivery. Targeted delivery of sirna therapeutics to malignant tumors qixin leng, 1 martin c. While ligand targeted liposomes have been reported to improve drug. Pdf ligand mediated drug targeted liposomes researchgate.
Pdf ligandtargeted liposomal therapies of neuroblastoma. Liposomal drug delivery systems for targeted cancer therapy. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Pdf liposomal drug delivery systems and anticancer drugs. In shaping lmdtls, a wide array of targeting ligands has been utilized.
Selective targeting of ligandtargeted liposomes containing anticancer drugs or therapeutic genes to cell surface receptors expressed on cancer cells is a recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics or gene therapeutics. Selected list of ligand targeted nanoparticulate systems evaluated for in vitro or in vivo therapeutics delivery. Pdf targeted delivery of sirna therapeutics to malignant. Liposomal nanoformulations as current tumortargeting approach. Accordingly, targeting the tumour vasculatures is essential for tumour treatment. Masking and triggered unmasking of targeting ligands on. Liposomal drug delivery systems and anticancer drugs mdpi. Some recent advances in the field of ligandtargeted liposomes for the treatment of cancer are summarized including. Development of ligandtargeted liposomes for cancer. Ligandtargeted liposomal anticancer drugs sciencedirect.